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Tuesday, November 15, 2011

“Metamaterial tiles” are hot in many applications – including invisibility cloak!


Various forms of metamaterial have generated a lot of scientific attention in the past few decades. Some exciting “potential” applications include the well-publicized invisibility cloak (Thanks to Harry Potter). As you may know already, metamaterial gains its bizarre optical property (such as negative index of refraction) by its internal composition or structure, rather than its original physical property. Most metamaterial has its magic only in specific wavelength region and this wavelength region is correlated to how small you can make the internal structures of the metamaterial. This is exactly why almost all the research on metamaterial focuses on THz region since THz has very long wavelength and we do not need to make the structures awfully small to concoct the magic (I did read some articles about “universal metamaterials”, but it seems a long way to go. Let’s dream of that coming in CLEO 2012).

Digging into more details, you can have 2D or 3D metamaterial depending on your applications. 2D metamaterial – or so called metamaterial tiles (m-tiles) – seems to make a huge leap in guiding the advance in the invisibility cloak and sensing platform. And they are easier to make (through the help of photo-lithography, or micro-machining on the surface). With this powerful combination, a booming in this field seems inevitable. Let us take a peek of its potential application in invisibility cloak first:

It is realized that for a TE plane wave, it is possible to have a perfect invisibility cloak providing that the metamaterial has the right permittivity and permeability. However this cloak has to have circular inner and outer boundaries. As far as we know, it is very difficult to make exact circular cloak even with nowadays technology. To get around it, certain compromise has to be made. Instead of using hollow sphere or cylinder, we can use hollow polyhedral, each facet of which is made by m-tiles. Having this idea in mind, research group in Germany carried out a simulation study, and the result is really promising. Polyhedral made by m-tiles will actually give quite satisfactory results, and it can hide the structure within it very well (figure 1). In some circumstance, you can even rotate the polyhedral without losing its cloaking magic.

Figure 1. An invisibility cloak made by a faceted dodecahedral. This simulation shows that the plane wave can propagate through it without too much distortion and objects can be hidden inside the dodecahedral. Courtesy of Oliver Paul, Yaroslav Urzhumov, Christoffer Elsen, David Smith, and Marco Rahm.
The powerful units of m-tiles have actually simple internal structures. Described in great details in this article, you can easily change (tune) its optical property by changing its size and shape. As shown as an example on figure 2, three hexagonal m-tiles of slightly different structures have different absorption peaks in THz region. This “easy to fabricate and tune ability” makes m-tiles more and more popular in the research world. Considering making these tiles on a flexible film, you can actually fold them into a functional shape with even more interesting applications. And maybe one day we will have some advanced mosaics made of various m-tiles.

Figure 2. Different shapes of Hexagonal m-tiles. Each side of the structure is ranging from a few um to tens of um. By slightly modifying the structures, each of them absorbs different THz frequency. This flexibility makes m-tiles very versatile. Courtesy of Christopher M. Bingham, Hu Tao, Xianliang Liu, Richard D. Averitt, Xin Zhang, and Willie J. Padilla in Optics Express 16 23 18565 (2008).
How about getting a step further -- making these m-tiles on the paper and transforming them to biosensor platforms? In a nutshell, researchers from Tufts University and Boston University use micromachining to fabricate micro-stencils on silicon nitride film. These micro-stencils have many of m-tiles on it. With the help of micro-stencils, they then imprint the pattern of the m-tiles on the paper by spraying on the paper substrates using electron beam evaporation (figure 3). Using this way, you can make as many m-tiles as you want! Now, this sensor is ready to be radiated by THz radiation. Since paper is relatively transparent in THz region, it is a very good substrate (a disposal one). Once the molecules have attached to the m-tiles, they will change the electric capacity of each m-tile. This change of capacity will reflect on the absorption peak of the m-tiles. And this makes it a good sensor for various molecules. In fact, this is quite a new way to sense the molecules. It can achieve the sensitivity of ~ mmole/L concentration. Not bad as a paper-based sensor!

Figure  3. Using micro-stencils to imprint as many m-tiles as you want on the paper! The inset shows how the absorption spectra of m-tiles are modified when different amounts of the molecules (in this case, urea) are attached to them. Courtesy of Hu Tao , Logan R. Chieffo , Mark A. Brenckle , Sean M. Siebert , Mengkun Liu , Andrew C. Strikwerda , Kebin Fan , David L. Kaplan , Xin Zhang , Richard D. Averitt , and Fiorenzo G. Omenetto in Adv. Mater., 23, 3197–3201 (2011).
In the near future, more applications of m-tiles can be seen, indeed.

Trip note:

Luckily, I attended several conferences in China at the end of October. I spent two weeks visiting several cities (Beijing, Wuxi, and Wuhan). In Wuhan – Optics Valley of China, I met student chapter of OSA in POEM 2011. I felt awesome! OSA had a booth, an eye catching poster, and a bunch of energetic students in this conference. It made me feel like home away from home. Way to go, OSA!

Figure 4. The poster behind OSA booth in POEM 2011, Wuhan, China. Energetic student chapter of China promoted OSA nicely. Felt so warm when I saw this.
DISCLAIMER
The opinions expressed herein are those of the author and do not represent the Optical Society of America (OSA) or any OSA affiliate.

Saturday, September 10, 2011

Zoo of super resolution microscopy.

Microscope, one of the most popular optical instruments, has been paving the way of biological science for the past three hundred years. With the aid of the microscope, detailed observations of sub-cell size resolution were made possible. This, in turn, accelerated our understanding of the biology in an unprecedented way. Three hundred years have passed; we now arrived at a new cross road -- While triumphing on the universe of biology, a desire to develop microscopes with specificities and better resolutions is creating another revolution.

Specificities problems are less optical relevant. It is like painting different organelles of the cell with different colors. To do so, scientists use fluorescent dyes to attach to different organelles or encode them directly into the genetic codes of the proteins. So we can differentiate what they are and where they are. Scientists are quite good in doing so.

Resolution is another story. It is a barrier imposed by fundamental physics. In other words, the enemy of a microscope is diffraction, which prevents how well you can resolve two points on the focal plane. Same principle also applies to how tight you can focus a collimated beam. Using the traditional microscope, you cannot have resolution better than hundreds of nanometers if visible light is used. The axial resolution is not much better. As a result, no matter how small the particle in the focal plane is (in this case, the fluorescent dye), you would always observe a blob with some sizable volume. How do achieve better resolution? What kind of tricks scientists can play to break the diffraction limit?

For me, the first milestone in super resolution is called FIONA (Fluorescence Imaging with One Nanometer Accuracy). What a lovely name! In a nutshell, it fits the fluorescent signal with a Gaussian function. By doing so, it finds the center of the dye theoretically. Just like finding a center of the blob in the example we gave above. This method is generally adopted in modern microscopy since it localizes the location of the dye in the lateral plane quite well. There is a caveat though -- you cannot have too many dyes in focal point. This is just going to screw up your fitting.

Same mathematical manipulation does not work satisfactory in axial direction. In addition to multi-photon microscopy which aims on attacking this problem, there are other neat techniques existent. The way to get around it is modifying and mixing the experimental setup with other optical phenomena. The most eye-catching technique to me is the research led by professor H. Hess in HHMI. By putting a three-way beam splitter, the florescent signal from the dye in the focal plane would interfere with itself and generate different interference pattern depending on how far the dye is offset from the true focal point. This method achieved tens of nm of axial resolution. What impresses me the most is the feeling I have when trying to understand the diagram of the experimental layout. Suddenly, you realize, the imagination to advance optical science is unlimited.


Figure 1. The optical layout for interference microscopy. Courtesy of G. Shtengel, et al. in PNAS 106 9 3125 (2009). 

Other neat ways emanate from bright minds also. One way to do so is to create bizarre spatial beam profiles at the focal plane. By putting an annular apodization mask, the work from the research group led by professor E. Betzig in HHMI created the Bessel beam profile at the focal plane. Combined with structural illumination, they created a focal spot, which has z resolution of less than 300 nm.  Another research group led by professor W. Moerner in Stanford used spatial liquid modulator (SLM) to create helix beam profile at the focal plane. With the help of de-convolution algorithm, they could localize a fluorescent dye with ~ 20 nm z resolution in a total of 2 micron depth. This is truly amazing.

Focusing the light into a tiny spot is not the only solution. In the branch of developmental and embryonic biology, the speed of taking the image with decent resolution is of prime concern. To solve this problem, scientists used a century old technique (using a tube lens to focus the light into a light sheet) with the modern spice of fluorescent labeling in the genetic level. Generated light sheet at the focal point excites a plane of fluorescent proteins in one shot. Research led by professor P. Keller (now in HHMI also) in European Molecular Biology Laboratory (EMBL) used this technique to elucidate the developmental process of a zebra fish embryo in the first 24 hours. A full digital documentation of the embryo is resulted. Optical science is delving very deep to search the origin of nature, isn’t it! A good website of light sheet microscopy can be found here!


Figure 2. Light scanned microscopy. The laser beam illuminated the sample from the side and excited the fluorescent proteins in the plane. Courtesy of  P. Keller et al. in Science 322 1065 (2008).

Coincidentally I found a very intuitive and interactive website for super resolution microscopy. It is like a power shot to everyone who is interested in knowing more in modern microscopy.


DISCLAIMER
The opinions expressed herein are those of the author and do not represent the Optical Society of America (OSA) or any OSA affiliate.


Saturday, July 30, 2011

Evolution, the master of optical science!

Do not get me wrong; evolution is an expert of all physical science. But it intimately links nature to optical science without doubt -- from cyanobacteria that have been converting solar energy to chemical energy for 3 billion years to human beings who rely on vision for surviving.

Neuroscience indicates that about 25%~ 50% of the brainpower and as many as 30 different areas of the brain are devoted to vision processing. This simply means that each human being is hard wired as an optical scientist, although we hardly recognize this. Over the past millions of years, evolution has perfected our imaging device in a subtle way. Recently, a report on Biomedical Optics Express shows for the first time the eyes’ imaging sensors -- cones and rods by using adaptive optics to minimize the aberration caused by the eye structure. As shown in the figure 1, cones, the round structures, create red, green, and blue perception of colors. There are about 6-7 millions of them, concentrated at the center of the retina -- forvea. A friendly and easy to digest article about this topic can be found here.


Figure 1. The cones in the fovea region of the eye. The retina is illuminated by 796 nm and 680 nm, respectively. The scale bar is 10 micron. Photo is courtesy of A. Dubra and Y. Sulai in Biomedical Optics Express Vol. 2 No. 6. 1757 (2011).

The other component of eye that always surprises me is the crystalline lens. It is 9 mm in diameter and 4 mm thick – a tiny optics. The structure of it is more or less like a transparent onion, formed by ~ 20000 very fine layers. Each layer is composed of cells of elongated shape (about a few micron thick and ~ 10 mm long). What makes it special is the variation of the index of refraction. In the inner core of the lens, the index of refraction is about 1.406, while it changes to 1.386 at the less dense cortex. This kind of design combined with the change of the lens shape makes us see things clearly whether they are far or close. In fact, evolution designs gradient index optics way before we even learned about it.

Changing the focus to animal kingdom, you can find more examples that not only make your eyes wide open, but also give us ideas to advance our knowledge of optical science. For example, Lobster uses reflective unit in the eye to focus much more light onto retina (figure 2a). This is definitely one of nature’s demonstrations on micro lens system. Mantis shrimp can detect circular polarized light thanks to intrinsic quarter wave plates made of cells in their eyes (figure 2b, for details about this work, here it is). You might wonder why we need to have polarized vision except 3D movie utilizing this principle to create stereo perception. Next time, when you buy sunglasses, get polarized ones. Wear them and observe the world! Asphalt road reflects light differently depending on light’s polarization. You can see that windshields are not that homogeneous in transmitting light any more. Due to its dichroism caused by tension when molding, it transmits one polarization better. Press a piece of thick plastic, and observe its change in transmission of light (you will induce dichroism by stress). LCD screens can only been seen clearly when you tilt your head in one direction. Turn your head in a different way, the screen become completely dark since most screens emit polarized light. After these daily life experiments, you might regret that we lose this feature during evolution.


Figure 2. (a) The reflective unit of a lobster's eye. (b) A cross section of the cells that work as quarter wave plate in the eye of Mantis shrimp. The scale bar is 10 micron. (c) The phase retardation introduced by the cells. They work nicely in the entire visible region of the light spectrum. The photo is courtesy of T.-H Chiou, S. Kleinlogel, T Cronin, and et al. in Current Biology 18 429 (2008).

We actually lose even more. Homo sapiens can only see three different colors, while birds, some mammals, and insects see the forth kind – Ultraviolet. For instance, Reindeer has UV eyesight. This special ability has evolution advantage. Lichen, on which the animal feeds, absorbs UV light, so it would appear black to reindeer eyes. The animal's traditional predator, wolves, would also appear darker against the snow, as their fur absorbs UV light. Apparently, under UV illumination, things are very different in polar area. I will suspect most of the animals living in Arctic or Antarctic area are endowed with this ability. How birds acquire UV vision is another fun story. Thanks to a beautiful article by Scientific American, bird’s UV vision is illustrated in details. A quick summary from this article: I realize our vertebrate ancestors had 4 types of cones in the eyes.  While birds inherit this feature, our mammal ancestors actually lost two of them! Fortunately, nature is kind to us. Through mutation, we regained a third variation of cones when walking down the evolution road. Without that mutation, we will all be color blinded!


Figure 3. How our perception of the colorful world improved, or degraded down the evolution road? Courtesy of Scientific American Magazine.
It is time for some wild experiment and conjecture. An article published on Nature in 2004 seems to tell us that the migratory avian creatures use the interplay of light, electrons, and earth magnetic field to guide their navigation. In a nutshell, it is called “radical-pair mechanism”. The light creates a coupling between an unpaired electron spin and nuclear spin through a light induced electron transfer. The earth’s magnetic field alters the dynamics of transitions between spin states. These transitions in turn affect reaction rates and products. Such effects can be amplified and used by the creatures. What does this tell us? Quantum mechanics and light matter interaction are working in a fine and elegant form. For a quick read, follow this link.

Story like this can be found at every corner on earth. After all, we are all offspring of nature, and nature relies on sun (the ultimate light source) in countless and ingenious ways. 


DISCLAIMER
The opinions expressed herein are those of the author and do not represent the Optical Society of America (OSA) or any OSA affiliate.

Tuesday, June 28, 2011

Interested in optical rulers? Well, which kind!?

Recently, three-dimensional plasmon rulers based on nano-rods are reported on Science. Hopefully, it will be cool weaponry for measuring the structures of the molecules in the near future. Over the past few decades, optical rulers based on different principles emerged from various branches of optical science. At the same time, researchers are trying hard to push each methodology to the limit. Optical Rulers, as a result, attract an army of researchers and spin off fruitful results. A quick summary of them seems to be a fair amount of content for everyone.

First thing first, what does an optical ruler do? Quite straightforward, it measures the dimensions of the molecular structures. For example, what is the distance between two subunits of a hemoglobin protein? What is the height of a membrane protein when measured from the membrane surface? Put into one sentence – optical rulers are aimed to map out the 3D structures of the molecules such that we can use this information to figure out the functionality of the molecules.

First ruler comes to your mind, I guess, will be the technique of X-ray diffraction. It is a true powerful optical ruler. After all, the DNA structure is solved by it, and Nobel Prize acclaims this technique for more than once. It has great resolution ~ 1Å, and you do not have put anything attached to the molecules. However, the pitfall is that, you have to crystallize the molecules which are merely impossible for some molecules, and the crystal forms of the molecules are in general, not the in vivo forms of the molecules. A report on C&EN and JACS beautifully illustrate the structure changes dramatically depending on the environment.

What is the king of in vivo optical ruler? I would say so far it is NMR. It has the resolutions of a few Å, and the algorithm is advanced so much that complex proteins are revealing their true forms (through more advanced multi-dimensional NMR). The principle is very similar to the trick we play with tuning forks. If you hit on one of the forks and bring the other replica close in, you feel the vibration on the second one and actually both will make the same tone without two touching each other. The energy (in terms of sound wave) resonates in these two forks. In NMR, intrinsic atomic spin plays the role of the tuning fork. By incorporate the isotopes (such as 1H 13C and 15N, these atoms have nonzero spins) into the amino acids of the proteins, the spins of these atoms behave like tuning forks with different tones. Imaging if there are two or more isotope atoms close to each other, the energy (in this situation, the microwave qunta) will be transferred between the isotopes (let’s say between 1H and 15N) assuming one of them is excited by microwave. NMR is specialized in measuring this energy transfer. The closer they are the more efficient energy transfer is. This efficiency drops proportional to 1/r^-6, where r is the distance between two spins. Now, if you have many of these isotope atoms located at different amino acids of a protein, you can figure out which isotopes (or more interestingly, which amino acids) are closer to each other. With the help of computer, you can infer the structures of the proteins, much like a complex trigonometry based on the relative positions of the spins.

Figure 1. A typical 2D NMR spectrum. Each blob can be thought as a sign of energy transferring between the spins of some specific hydrogen and nitrogen. By doing this kind of cross mapping, we can figure out the 3D structure of the molecules.
Two other techniques, Förster resonance energy transfer (FRET) & multi-dimensional IR spectroscopy, utilize similar principles we just described. In FRET, fluorescent dyes are attached the molecules of interest and lasers with optical frequencies are often used. If you excite one of the dye with the laser, and if the second dye is very close to the first dye, you can actually observe the light emitted from the second dye, much like the tuning fork instance we mentioned. It has the resolution of ~ nm and is widely used in biological society. On the other hand, multidimensional IR spectroscopy uses intrinsic vibrational modes of the molecules, such as the stretching mode of C=O. C=O is abundant in a protein which makes it very attractive. Through this technique, you can follow the energy is transferring from one C=O to another, and figure out the distances between two amino acids. The resolution is also in the Å scale. Another neat thing about it is that, multi-dimensional IR is able to monitor the structural change in fs to ps time scale, and this makes it very unique.

Last but not least, let’s touch the topic that initiates this short article – an optical ruler based on plasmon. As you may already learn, the plasmon is some electrons oscillating on the surface of a nano-rod. Lasers with optical frequencies are very effective in exciting these plasmon modes. Another thing you also need to know is that, plasmon modes are sensitive to the surrounding, especially when there are other nano-rods around. Again, just like the tuning fork, energy (in terms of plasmons) that locates on one nano-rod can hop onto another nano-rod. The efficiency of this hopping, and the resonant frequency of the plasmon mode are highly dependent on the overall geometry of the nano-rods and the distance among them. This is the principle we are applying. The ruler is composed of 5 nano-rods (figure 2), carefully spaced to each other. Depending on the overall geometry, the transmission spectra of the ruler is changing dramatically. This change serves as a “legend” for 3D mapping (figure 3). 

Figure 2. 3D layout of the plasmon ruler. The nano-rod in the middle has a dimension of  40*80*260 nm and is directly excited by the light source. Courtesy of N. Liu, M. Hentschel, T. Weiss, A. Alivisatos, and H. Giessen in Science 332 1407 (2011).

Figure 3. Depending on the relative position of the middle rod with respect to the other four, the transmission at certain wavelengths (as pointed out as resonance I and II) changes dramatically. This is the optical legend that can be used to infer the relative positions of the rods. Courtesy of N. Liu, M. Hentschel, T. Weiss, A. Alivisatos, and H. Giessen in Science 332 1407 (2011).
The future goal will be attaching this genre of nano-rods onto different domains of the molecules and monitoring the spectra of them. By doing so, you can figure out the distance among the rods and then map out the distances among different domains of the molecules (figure 4).

Figure 4. By attaching the nano rods (shown in yellow) onto different domains of the molecule, we can infer the 3D structure of it by interpreting the spectra of the nano rods. Courtesy of A. Mastroianni, S. Claridge, and A. Alivisatos in JACS 131 8455 (2009).
Well, next time when people are interested in optical ruler, maybe you should just say: “which kind of them are you interested!?”

DISCLAIMER
The opinions expressed herein are those of the author and do not represent the Optical Society of America (OSA) or any OSA affiliate.

Tuesday, May 10, 2011

CLEO/Europe EQEC 2011 is ready to relay the success of CLEO US.

Just like the movie slogan, “everything that has a beginning has an end” (I should reverse this to make it more suitable for this short blog). Everything that has a terrific end has a new exciting beginning. Indeed, something electrifying is happening across the Atlantic. Every two year, CLEO/Europe EQEC 2011 (22-26 May, Germany) is taking the heat to Europe and once again is looking forward to resonating what we have just completed in CLEO.

For people like me, who doesn’t have the luxurious time and funding to enjoy another wonderful trip, you can easily find the detailed programs in this link. Once you click the link and scrutinize the abstracts, I hope you don’t get trapped. For sure, the conference is loaded with crazy and smart ideas. Here are just some I found:

EE1.5 SUN 10:00 “The Size of the Proton” -- This rings the bell in my brain. I read about this in Scientific America a few months ago, and that sticks to my mind. On the one hand, I simply have no idea how laser spectroscopy can be used to measure the radius of the proton. There must be some original way, to me, a proton is almost dimensionless. On the other hand, they give a more precise but exotic value of it. Would this value forces the theoretical particle physicists to re-think what they have formulated for the past decades?

JSII1,2: “Low Dimensional Carbon Nano-Structures in Photonics I, II” -- Apparently, the Nobel prize simply marks the beginning explosion of the graphene related research. We are familiar with the novel material features of graphene and nanotubes. In addition to investigate their physical properties using lasers, how about using them to mode-lock a laser? Or using double wall carbon nanotubes to create broadband ultrafast pulses? Sit in these presentations, and you will find out.

CL/EB1-3 “Medical Imaging, Advanced Microscopy, Advanced Biophotonics: Sensing and Imaging” -- This is where you find yourself accessing the fresh. For people who are fond of applications, these are the harbors. It is simply a zoo of creative methodologies. I like the techniques that play around with the light polarizations. You might enjoy using nanoparticles to be the bio-markers. Just explore them and make your own list of preference.

OK, Time for you to take this journey to Germany, either physically or virtually. The destination is the same for all of us. Remember to check out the plenary sessions -- from attosecond lights, and insights of the cold atoms/molecules, to the advances of solid-state lasers. Feels like another feast to me. Finally, don’t get me wrong, almost everything that discussed in CLEO, you can find the continuation of them in CLEO/Europe EQEC 2011. I will leave you to connect the dots. Cheers!

DISCLAIMER
The opinions expressed herein are those of the author and do not represent the Optical Society of America (OSA) or any OSA affiliate.

Friday, May 6, 2011

Fully Charged, will be back for more next year!

Just want to touch a few more fields before we wrap up this amazing CLEO 2011. The truth is, we all learn a lot and we will crave for more soon.

I guess we are by now all familiar with the metamaterials thanks to the powerful broadcasting media and online news. Metamaterials have some complex indices of refractions, which bend the light in a whole new way. Even nature utilizes it. The amazing colors on the butterflies, insects, are all originated from the nanostructures – some variations of metamaterials. However, I realized yesterday, this is OLD news.

Researchers now have something new called (well, new to me) “configurable metamaterials”. Unlike before, a specific metameterial is only suitable for one frequency; nowadays we can tune the properties of them by varying the temperature, through optical pumping, and more. If we use some materials that have strong thermal or optical responses to construct the metamaterials, these phoeneoma can be achieved. The concept seems to be there for quite a while, but it is just thrilling to see the real works have been done.

This morning, Dr. John E. Bowers gave an amazing talk on silicon photonics. I feel like soon in the future, silicon will replace the metallic wires in the computer, become the light source of miniature sizes penetrating to our daily lives, and constitute the cores of our gadgets. Furthermore, the data transmission rate is much higher (with tens of GBs per second, more than enough to watch all channels of HDTV at once), and the heat generation is negligible compared with the computers of modern days.

Make sure you check the article in photonics spectra and this one in from Intel to peek the future. Think about it, if we have the silicon-based waveguide/lasers of tiny dimensions, combined with flexible LED panels, we can make the electronics so small and life will totally be awesome.

In addition to using silicon as data transmission media, a hybrid silicon ring laser, like the three shown here, could be used as an on-chip light source in future photonic circuits. The rings are just 12.5 µm in radius and consist of III-V compound semiconductors. Waveguides – the black lines running below the rings – traffic the light back and forth. (Courtesy of Di Liang, University of California, Santa Barbara).
Fiber lasers/amplifiers have drawn huge amount of attention in the past decade. The Holy Grail is to replace the free space lasers in many applications. If they succeed in doing so, I would imagine all the laser-based medical devices would use fiber lasers since they can be made compact, robust, and essentially free of aligning. They can even revolutionize the optomechanics’ market (apparently, a lot of free space optomechanics will be forced to retire). Like past few years, great advancement/or continuous improvement are seen in this conference, such as mode-locked fiber lasers, fiber amplifiers, fiber parametric devices, new wavelength fiber lasers, beam combining and stabilization of fiber amplifiers, and even fiber based sensors (browse your brochure one more time if you are too busy to notice these).

Advances in biological microscopy and nanophotonic sensors once again carry the light applications into another degrees of freedoms. There are numerous ways of doing microscopy, old and new, classical and bizarre. Some promise more while the other create intellectual and instrumental challenges. Each category of them suggests a new direction for laser manufacturing. I guess this is part of the fun in research pioneering! On the other hand, advances in nonophotonic sensors do make me realize we have to re-think the limitation of “instrumental sizes” almost every time you think about it. Indeed, researchers give you a new definition of instrumental size almost every year!

See you all in next CLEO or actually next conference!


DISCLAIMER
The opinions expressed herein are those of the author and do not represent the Optical Society of America (OSA) or any OSA affiliate.

Thursday, May 5, 2011

Applaud with appreciation to all the poster session’s presenters!!!

Attending poster sessions is energetic and adventurous. It is even a great social event. Compared to technical session, you never fall asleep and you can interrupt the presenters whenever you want (How great is this, you simply have a personal tutor at your disposal). In additions, you learn more in less time if your mind is a knowledge sponge.

Forgive me for sampling only today’s poster session. Actually I totally regret I didn’t spend enough time in the last few days for poster sessions. To me, these successfully poster sessions really mark one of the highlights in CLEO 2011. Here are some of them that I got a chance to interrogate the presenters (they were just busy, it was quite hard to squeeze in to ask even one question):

JThB8, Generation of a macroscopic singlet state in an atomic ensemble – I learned from this poster that you can create a spin 0 ensemble using weak optical pump coupled with active feedback. In other words, you start from cold atoms and squeeze the distribution of the spins in a way that it approaches zero expectation values in all directions through a tailored Hamiltonian. Quite amazing, but it has been realized beautifully by the researchers.

JThB25, Twin-photon correlated confocal microscopy – the lateral resolution of the microscopy is defined by the diffraction limit. A clever way to improve the resolution for more than 60% is proposed and performed by utilizing a phase plate right in front of the sample. In a nutshell, the phase plate encodes different phases for the points that are not in the vicinity on the sample. If the points on the sample were more separated, the imposed phase would be more different. A smart detection scheme then only picks up the signals that have no phase difference. By doing so, the light from one point on the sample is amplified and that from points nearby are suppressed. This greatly enhances the lateral resolution.

JThB28, Photon-phonon entanglement in a coupled optomechanical system – the entanglement of photon and phonon is studied thoroughly in this simulation work. A system with two coupled optomechanical cavities is the model system (imagining one side of the cavity is on a spring, so this cavity supports phonon modes). Two cavities are coupled by cavity-supported light modes. It is found that the light can couple the photon modes to the phonon modes of the cavity. And this entanglement lasts more than 500 seconds. This really blows my mind away; I used to think the entanglement doesn’t sustain itself for this long.

JThB42, Conical interaction dynamics in a rhodopsin analog: isorhodopsin – Ultrashort pulses (~ 10 fs) from NOPA are used to investigate the isomerization of rhodopsin (the first chemical reaction in the mechanism of “seeing things”) and isorhodopsin. By compared with the results of isorhodopsin, it is found that the isomerization of the rhodopsin molecule is actually optimized on the right chemical bond location. As a result, the efficiency is superb. Nature does her job, indeed!

JThB45, Unidirectional perfect transmission resonances in nonlinear asymmetric photonic multilayer – Combining theory and experiment, a photonic crystal multilayer, which transmits light in one direction but not the other, is realized. In one direction, the transmittance is more than 92% (the reverse direction, the transmittance is less than 20%). This is actually a one-way photonic crystal and I think applications based on this will come in the near future. The presenter is so nice and gives me some advice on the technical session -- His way of arranging the chairs will definitely increase the seating capacity by at least 2-fold. Your opinion is greatly appreciated.

JThB137, A comparative study of Raman enhancement in capillaries – OK, I have to admit, I love this one. The experiment is straightforward but so smart and neat. The laser light is guided through a hollow photonic crystal fiber by a high NA objective. The hollow fiber is filled with the solution of the chemicals. The light has very high photon density in the fiber and the interaction length of the chemicals with the light in the fiber is long. Subsequently, the Raman signal is found to increase by ~ 10-fold. 10-fold is an astronomical number to me actually, but the result confirmed this nicely done work.

Thanks again to all the poster session presenters! Bravo!!!

p.s: Just realize there is a Light Street right beside Baltimore convention center. Maybe that is why we have CLEO 2011 here!?

Light Street, Baltimore, MA!!!
DISCLAIMER
The opinions expressed herein are those of the author and do not represent the Optical Society of America (OSA) or any OSA affiliate.

Wednesday, May 4, 2011

When light dances with sound, teases the molecules, and plays an important role in green energy!

Shuffling among many eye-opening technical sessions and CLEO’s Market Focus & Technology Transfer Showcase, I simply realize adventures with light are everywhere:

An amazing imaging technique called photoacoustic imaging/microscopy (JTuG) caught my full attention on Tuesday. It is a perfect example of light collaborating with sound to achieve something fascinating.  Think about it, light and sound are siblings. They are governed by similar natural laws. You might argue that light can propagate in vacuum while the sound needs media to do so. But again, they are siblings, not twins. So this argument does not really hold. Anyway, taking that into account, isn’t it fun to see them hold hands and work on something new together!?

The principle behind this new imaging technique is actually straightforward. The pulsed laser light (MHz repetition rates) is focused into the tissue; the tissue of interest absorbs the light and expands. This process is repeated with laser repetition rate. The pulsed expansion creates the ultrasonic sound wave, and we detect this by transducers. We then reconstruct the image of the tissue through some complex algorithm. We know that ultrasonic can penetrate deep tissue, while the resolution of ultrasonic is not as great as optical imaging. On the other hand, optical imaging can only go to a few millimeters deep. By endeavors of the researchers in improving this technique, photoacoustic imaging actually combines the strength of these two – it can do deep tissue imaging with optical imaging resolution – optical resolution photoacoustic microscopy.

An experimental layout for photoacoustic microscopy.
Fast-forward to Wednesday, a wonderful QELS session (QWB) focusing on laser cooling and its further applications on quantum computations and simulations are really hardcore stuffs. Using light to produce ultra cold molecules is definitely pushing the frontiers of science. We all heard of atoms cooled by lasers and a Nobel Prize was given to this achievement. But for molecules, things are more difficult. They have inertial structures and as a result, complicated processes are involved when cooling them by laser light. However, diatomic molecules are being cooled to sub micro Kevin through Sisyphus and Doppler cooling (check this article for more). If you missed today’s presentations, it is totally ok. On Thursday, sessions like QThJ, QThM, QThN, and QThO will feed your quantum hunger.

Talking about green energy, Laser Inertial Fusion Energy (LIFE) is discussed during CLEO’s Market Focus. Due to human mankind’s need in energy, we turn to fusion, and we intend to do so by using extremely high power lasers. LIFE utilizes 384 powerful lasers to create pulses with the energy of 3.1 mega Joule in IR and 2.2 mega Joule in UV per pulse. Each laser has the size of a truck and can be swapped in and out as a unit if the lifetime is reached or malfunction is found. This kind of gigantic project requires the state-of-art techniques and actually drives the development of the optical industry, such as glass productions. If you dig even further, the diode pumped helium cooled mercury amplifier inside each laser is just breathtaking. The helium is blown through the gain media with 0.1 Mach speed to cool down the laser. In other words, you even need aerospace technology to prevent the turbulence inside the laser.

Finally, also thanks to CLEO’s Market Focus & Technology Transfer Showcase, I just learned that an animated website created by JDSU called Photovoltaic for generating and measuring energy is a good starting point to know how light plays the role in green energy. Enjoy it and do not forget to check out CLEO’s Technology Transfer Showcase program tomorrow.


DISCLAIMER
The opinions expressed herein are those of the author and do not represent the Optical Society of America (OSA) or any OSA affiliate.

Tuesday, May 3, 2011

Behind every successful conference!!!

An exciting conference is mainly composed of two parts – technical sessions and exhibition. We enjoy the technical sessions because that’s where we learn from our peers, get our brainstorms, and have a quick update on the scientific frontiers. These are addicted as you can tell me about it. However, ask yourself about the definition of a successful conference. Most of us will say a conference will not be complete without stopping by the exhibition hall to see the zoo of new products and technologies presented by numerous companies. Well, the souvenirs we gather from each booth are attractive too!


If we take a step back, we realize that convention center is a very busy host. Every week it is embracing a new show and new people with crazy ideas. This makes me wonder, what kind of preparation is required to host a welcoming conference? For technical sessions, things are easier to picture since most people had the opportunity to observe or organize a symposium either in the school or in a research institute. We need to multiply everything by at least a hundred. These are OK, we can have more rooms, chairs, projectors, laser pointers, and most importantly, more coffee and labor. So we can make this happen. Now, if we think about the preparation of an exhibition hall, a blank image usually emerges. I did not even know how an exhibition hall looks like before all the companies fight for the space and start to build their own territories, not even mention about how to set it up. Thanks to my job duty and helps from the colleagues, now I have observed the way it happens…^_^


The convention center is moving at a very fast pace as we mentioned. The first thing we have to realize is the time you have to build a booth. Normally, each company has a full day working with the labor of the union to set up everything. In other words, people are working under great pressure. The very first scene I saw is that everyone on the floor was tense since all they faced is a concrete floor marked by chalk to specify the territories of each company. Phones were ringing all the time because on the other side of the exhibition hall, hundreds of trucks were waiting to ship the equipments into the hall. In the meanwhile, experienced workers maneuvered loaded carts, and crates were shuffling among people. These would go on for several hours, and step by step, each big and small cargo reached the right destination, while small hassle was happening all over the place (such as some trucks got lost, according to the workers, this is quite normal).



Small carts moving around the cargos and magically they all arrive at the right destinations.
After this was all set, locating the power jackets and building tiny power grids on the floor were next. We can fairly say, without the electricity, the exhibition hall would be like a haunting house rather than a technology showcase. But for the beauty of the exhibition, we want to hide these power grids. So we make them lying comfortably on the floor and covered by carpet later on. By doing so, we will never spot them unless you come to the hall before the grand opening. At the same time, small hydraulic trucks were busy putting the overhead canvas slogans and signs above company’s booth. From this moment on, we would not get lost, since the flag (well, the slogan) was waving on each and every corner of the hall.


The power grids (shown in orange) on the floor are taped down nicely and distributed very efficiently for the booth use. 
Time to do some makeup. The “base foundation” was the carpet. It covers all the power grids and jackets, all the chalk signs, and marks the lanes of the traffic. Putting the carpet represents an important step – “the equipments are ready to get some fresh air.” Knowledgeable technicians started to open the crates (always with complaining, since equipments had legs, they moved around after staying in the trucks for so long), tried to do preliminary assembling, and finalized the floor plans. They spent another several hours to put optical tables together, made the equipments up and running, and arranged and cleaned the surfaces of each components. These are tedious work, and work was again under great pressure.


This booth is about 50% done. Technicians have been working for hours, and there are still al of of crates need to be opened and arranged on the optical tables.
Just like LEGO we played when we were young, setting up the booth was like intense LEGO works, except they are much bigger and you cannot quit if you feel tired. It is not uncommon to see people work way beyond midnight because they want to present the best to the researchers and the students the following day. After technicians and the product line managers were satisfied with the setups, final cleanup was required. Final vacuuming on the floor, tearing open the plastic wrapping of the carpet, and covering the equipments and tables with blanket were essential works not to be omitted.  Everyone wanted to keep every link neat and flawless.


After a detailed inspection on the booth, we can call it a day. Hmmm, time for bed or time for a drink?! I would like to thank Mr. Hoang Hung and John Carter, the men who are in charge of the booth setup. Without his help and explanation on the details, I will not be able to peek through this new window to see how to dress the conference!


Another successful show!!! After seeing so much traffic, all the efforts and sweats are just sweet!
DISCLAIMER
The opinions expressed herein are those of the author and do not represent the Optical Society of America (OSA) or any OSA affiliate.